Research Fellows and Engineering Fellows

Mie Kaino PhD

Department :
Pharmaceutical Research Laboratories
Area of expertise :
Pharmacology and Drug Discovery

My research philosophy

As the society will continue to age, the engine of growth for our company is life innovation in drugs and medicine. I want to contribute to the further progress and global expansion of our drug business by continuing to discover highly original drugs. I also want to contribute to making our company more renowned name in life science by driving life innovations covering the fields of both drugs and medicine. But more importantly, I will dedicate myself to the innovative research for the future by believing that "Research" is what makes Toray of tomorrow and being true to my motto of "The Deeper, the newer."

Key academic papers

1990 Production of cytokines of LGL. Clinical Immunol. 1990;22:1153.
1991 Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level. Biochem Pharmacol. 1991; 41:1135.
ADP-induced platelet adhesion to collagen in platelet-rich plasama under blockade of GPIIb/IIIa function. XIII Congress of the international Society on Thrombosis and Haemostasis. 1991; 65:1110.
1992 Glycoprotein Ia/IIa-mediated activation-dependent platelet adhesion to collagen. Thromb Res. 1992;65:165.
2001 Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa- associated src and protein tyrosine phosphorylation J Biol Chem. 2001;276(2):1643.
Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1) Blood 2001;98(13):3708.
2002 Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions. Blood 2002;100(1):136.
Production of soluble integrin alpha2beta1 heterodimer complex functionally active in vitro and in vivo. Biochem Biophys Res Commun 2002;290:305.
2006 Novel orally active alpha4 integrin antagonist, T-728, attenuates dextran sodium sulfate-induced chronic colitis in mice. Gastroenterology 2006;130:A352.
2008 Orally active small molecule alpha4beta1/alpha4beta7 integrin antagonist, T-728, reduces chronic colitis in animals. Gut 2008, 57: P1155.
2014 Inhibitory effects of an orally active small molecule alpha4beta1/alpha4beta7 integrin antagonist, on spontaneous colitis in HLA-B27 transgenic rats. Gastroenterology. 2014;146:S640.