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Toray, Fresenius Medical Care Sign Exclusive Distribution Agreement for Acute Blood Purification Devices in 8 European Countries

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Sep. 16, 2014

Toray Industries, Inc.

Toray Industries, Inc. (Head office: Chuo-ku, Tokyo; President: Akihiro Nikkaku; hereinafter referred to as “Toray”) announced today that it signed exclusive distribution agreement covering eight countries in Europe with Fresenius Medical Care AG&Co KGaA (headquarters: Bad Homburg; CEO: Rice Powell; hereinafter referred to as “Fresenius Medical Care”) regarding TORAYMYXIN®*1,*2, a blood purification device for removing endotoxin and PMMA hemofilter*3,*4 for continuous renal replacement therapy, produced by Toray. This agreement awards Fresenius Medical Care the exclusive rights to sell the products in these countries.

Ever since its introduction in 1994, TORAYMYXIN® has been used in clinical practice primarily in Japan to treat severe sepsis and septic shock.
PMMA hemofilter, which is made with polymethylmethacrylate (PMMA) hollow fiber membrane, received approval for manufacturing in 1991 and has been used successfully in many cases, mainly in the emergency and intensive care field to treat acute renal failure and to support organ dysfunction.
With the alliance Toray further expands the market for acute blood purification products in Europe, while Fresenius Medical Care enhances its product lineup with new blood purification products in Europe.

Under the corporate slogan "Innovation by Chemistry," Toray sets out to become "a global top company of advanced materials" by pursuing innovation based on chemistry. For this purpose, it will drive forward creation of new products and technologies by leveraging core technologies of organic synthetic chemistry, polymer chemistry, biotechnology and nanotechnology. The Toray Group also aims to expand the business in the life science field, which it positions as one of "Intensively Developing and Expanding Businesses” that are growth engines under the medium-term management program Project AP-G 2016.


―Countries covered by the sales agreement―
Germany, Denmark, Sweden, Finland, Norway, Poland, Hungary, Czech

*1 TORAYMYXIN® has been sold in Japan since its approval by the Ministry of Health and Welfare in 1993(approval number: 20500BZZ00926000).
*2 TORAYMYXIN® was declared to meet the provisions of the required EC Council Directives and Standards in 1998 and has been sold in some European countries under the CE Marking since 2002.
*3 PMMA hemofilter has been sold in Japan since its approval by the Ministry of Health and Welfare in 1991 (approval number: 20300BZZ00624000).
*4 PMMA hemofilter is under application in regard to meet the provisions of the required EC Council Directives and Standards.
 
<Glossary>
Sepsis
Organ dysfunction caused by host response to infection. Endotoxin (gram-negative bacterial cell wall component ) could play an important role to trigger host response. In more severe cases, the patients develop septic shock accompanied with circulatory failure. These eventually induce multi-organ dysfunction syndrome and death.
Acute renal failure
Acute renal failure indicates the condition in which the function of kidney deteriorates rapidly. Under this condition, the patients would not be able to regulate body fluid and electrolyte balance, needing blood purification treatment.
Continuous renal replacement therapy
It is treatment that removes gently waste from the blood over a long duration. Its advantage is that it has less impact on hemodynamics of the patients.
 
<Company profile>
Fresenius Medical Care AG&Co KGaA
Headquarters
Bad Homburg, Germany
CEO
Rice Powell
Fresenius Medical Care is the world's largest integrated provider of products and services for individuals undergoing dialysis because of chronic kidney failure, a condition that affects more than 2.5 million individuals worldwide. Through its network of 3,335 dialysis clinics in North America, Europe, Latin America, Asia-Pacific and Africa, Fresenius Medical Care provides dialysis treatments for 280,942 patients around the globe. Fresenius Medical Care is also the world's leading provider of dialysis products such as hemodialysis machines, dialyzers and related disposable products.

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